Chromium Picolinate is, besides chromium polynicotinate, a nutritional supplement designed to avoid or treat chromium deficiency. Insulin requires some modest levels of chromium in order to utilize glucose in healthy individuals. There is no record of chromium deficiency occurrences in regular population, only prolonged dieters in clinically observed and controlled obesity reduction treatments have registered any. Clinical trials have suggested that chromium picolinate may have antidepressant qualities, when applied to patients with atypical depression. Further observation signaled a reduction in carbohydrate cravings and seemed to regulate appetite. These results led to the incorporation of chromium picolinate into supplements for athletes who are working on body development and are looking to lose weight. It has been also observed that chromium picolinate is able to boost the blood levels of insulin for a limited time.

Gymnema Sylvestre is an herb that has shown to reduce blood sugar and is used by some to reduce sugar cravings as it seemingly reduces the sugar taste when placed in the mouth.

Hydrocitric Acid is taken from the rind of Garcinia Cambogia and has been known to aide in weight loss.